Drug interactions
Deferasirox + Erlotinib
Severity: Moderate
Deferasirox and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and may lower erlotinib levels, but it also inhibits CYP2C8 and CYP1A2, so the net effect is uncertain. Erlotinib efficacy could be reduced.
What this interaction means in plain words
Deferasirox and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Erlotinib belongs to Oncology.
Why it happens
Deferasirox may induce CYP3A4 metabolism of erlotinib; the net effect is not firmly established.
What to do
Monitor clinical response to erlotinib and for unexpected toxicity. Adjust erlotinib dosing based on response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Erlotinib?
MediHelp rates the interaction as moderate. Deferasirox and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and may lower erlotinib levels, but it also inhibits CYP2C8 and CYP1A2, so the net effect is uncertain. Erlotinib efficacy could be reduced.
How serious is the interaction between Deferasirox and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to erlotinib and for unexpected toxicity. Adjust erlotinib dosing based on response and tolerability.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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