Drug interactions
Deferasirox + Etrasimod
Severity: Moderate
Deferasirox and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is cleared by CYP2C8, CYP2C9 and CYP3A4. Deferasirox inhibits CYP2C8, which may raise etrasimod exposure, especially in CYP2C9 poor metabolizers who rely more on the other pathways.
What this interaction means in plain words
Deferasirox and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Deferasirox inhibits CYP2C8, reducing etrasimod metabolism.
What to do
Avoid the combination in known CYP2C9 poor metabolizers. In others, monitor heart rate and for etrasimod adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Deferasirox with Etrasimod?
MediHelp rates the interaction as moderate. Deferasirox and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod is cleared by CYP2C8, CYP2C9 and CYP3A4. Deferasirox inhibits CYP2C8, which may raise etrasimod exposure, especially in CYP2C9 poor metabolizers who rely more on the other pathways.
How serious is the interaction between Deferasirox and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in known CYP2C9 poor metabolizers. In others, monitor heart rate and for etrasimod adverse effects.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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