Drug interactions
Deferasirox + Flurbiprofen
Severity: Major
Deferasirox and Flurbiprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can itself cause gastrointestinal ulceration and hemorrhage, and NSAIDs add further mucosal damage and antiplatelet effects. The combination increases the chance of serious GI bleeding, and both agents can also affect renal function.
What this interaction means in plain words
Deferasirox and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and bleeding tendency, with possible additive nephrotoxicity.
What to do
Avoid the combination where possible, or use gastroprotection and monitor for GI bleeding, hemoglobin and renal function. Consider paracetamol or another non-NSAID analgesic as an alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Flurbiprofen?
MediHelp rates the interaction as major. Deferasirox and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can itself cause gastrointestinal ulceration and hemorrhage, and NSAIDs add further mucosal damage and antiplatelet effects. The combination increases the chance of serious GI bleeding, and both agents can also affect renal function.
How serious is the interaction between Deferasirox and Flurbiprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use gastroprotection and monitor for GI bleeding, hemoglobin and renal function. Consider paracetamol or another non-NSAID analgesic as an alternative.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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