Drug interactions
Deferasirox + Ibuprofen
Severity: Major
Deferasirox and Ibuprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the gastrointestinal mucosa and cause ulceration and hemorrhage, and both can affect renal function. Together they raise the risk of serious GI bleeding and kidney injury.
What this interaction means in plain words
Deferasirox and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Ibuprofen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxicity, with NSAID-related platelet inhibition adding to bleeding risk.
What to do
Avoid combining where possible; if unavoidable, monitor renal function and for GI bleeding, and consider gastroprotection. Choose a non-NSAID analgesic when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ibuprofen?
MediHelp rates the interaction as major. Deferasirox and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the gastrointestinal mucosa and cause ulceration and hemorrhage, and both can affect renal function. Together they raise the risk of serious GI bleeding and kidney injury.
How serious is the interaction between Deferasirox and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if unavoidable, monitor renal function and for GI bleeding, and consider gastroprotection. Choose a non-NSAID analgesic when possible.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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