Drug interactions
Deferasirox + Imipramine
Severity: Minor
Deferasirox and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox is reported to induce CYP3A4 and inhibit CYP2C8 and CYP1A2, so imipramine exposure may change. Imipramine is metabolized by multiple pathways, so the net effect is uncertain and probably small.
What this interaction means in plain words
Deferasirox and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
Deferasirox may alter CYP3A4 and CYP1A2 mediated metabolism of imipramine; direction of net effect is not well established.
What to do
No routine adjustment is needed; monitor clinical response and anticholinergic or cardiac adverse effects of imipramine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Imipramine?
MediHelp rates the interaction as minor. Deferasirox and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox is reported to induce CYP3A4 and inhibit CYP2C8 and CYP1A2, so imipramine exposure may change. Imipramine is metabolized by multiple pathways, so the net effect is uncertain and probably small.
How serious is the interaction between Deferasirox and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response and anticholinergic or cardiac adverse effects of imipramine.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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