Drug interactions
Deferasirox + Ketoconazole
Severity: Minor
Deferasirox and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may lower ketoconazole concentrations and weaken antifungal efficacy, although the effect on CYP3A4 by deferasirox is variable and incompletely characterised.
What this interaction means in plain words
Deferasirox and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Ketoconazole belongs to Anti Fungals.
Why it happens
Deferasirox may induce CYP3A4 modestly, increasing ketoconazole metabolism; the mechanism is not firmly established.
What to do
Monitor for antifungal treatment failure and consider ketoconazole level assessment or an alternative if response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deferasirox and Ketoconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ketoconazole?
MediHelp rates the interaction as minor. Deferasirox and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox may lower ketoconazole concentrations and weaken antifungal efficacy, although the effect on CYP3A4 by deferasirox is variable and incompletely characterised.
How serious is the interaction between Deferasirox and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antifungal treatment failure and consider ketoconazole level assessment or an alternative if response is poor.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
