Drug interactions
Deferasirox + Metformin-pioglitazone
Severity: Moderate
Deferasirox and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and inhibit CYP2C8, so its net effect on pioglitazone exposure is uncertain. Pioglitazone is cleared mainly via CYP2C8, so inhibition by deferasirox may raise exposure and the effect on glucose control or fluid retention could be amplified.
What this interaction means in plain words
Deferasirox and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Deferasirox inhibits CYP2C8 (the main pioglitazone pathway) and induces CYP3A4, giving an unpredictable net change in pioglitazone levels.
What to do
Monitor blood glucose and for edema or heart failure signs when starting or stopping deferasirox; reduce the pioglitazone dose if exposure appears increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Deferasirox and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and inhibit CYP2C8, so its net effect on pioglitazone exposure is uncertain. Pioglitazone is cleared mainly via CYP2C8, so inhibition by deferasirox may raise exposure and the effect on glucose control or fluid retention could be amplified.
How serious is the interaction between Deferasirox and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for edema or heart failure signs when starting or stopping deferasirox; reduce the pioglitazone dose if exposure appears increased.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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