Drug interactions
Deferasirox + Methadone
Severity: Moderate
Deferasirox and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and may lower methadone concentrations. This could reduce analgesic effect or lead to withdrawal in patients on maintenance therapy.
What this interaction means in plain words
Deferasirox and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Methadone belongs to Musculoskeletal.
Why it happens
Deferasirox induces CYP3A4 and increases methadone metabolism, though the effect is variable.
What to do
Monitor for loss of effect or withdrawal symptoms after starting deferasirox and titrate the methadone dose as needed. Reassess the dose if deferasirox is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Methadone?
MediHelp rates the interaction as moderate. Deferasirox and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and may lower methadone concentrations. This could reduce analgesic effect or lead to withdrawal in patients on maintenance therapy.
How serious is the interaction between Deferasirox and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of effect or withdrawal symptoms after starting deferasirox and titrate the methadone dose as needed. Reassess the dose if deferasirox is stopped.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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