Drug interactions
Deferasirox + Nilotinib
Severity: Moderate
Deferasirox and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower nilotinib levels, potentially reducing efficacy. The effect is considered modest.
What this interaction means in plain words
Deferasirox and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Deferasirox induction of CYP3A4 increases nilotinib clearance.
What to do
Monitor molecular response and consider nilotinib levels if available. Reassess iron chelation choice if response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Nilotinib?
MediHelp rates the interaction as moderate. Deferasirox and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and lower nilotinib levels, potentially reducing efficacy. The effect is considered modest.
How serious is the interaction between Deferasirox and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor molecular response and consider nilotinib levels if available. Reassess iron chelation choice if response falls.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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