Drug interactions
Deferasirox + Pazopanib
Severity: Moderate
Deferasirox and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and reduce pazopanib exposure, though the effect is not well characterized. Both drugs can also affect liver and kidney function.
What this interaction means in plain words
Deferasirox and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Possible CYP3A4 induction by deferasirox; additive hepatotoxic potential.
What to do
Monitor liver function tests and renal function regularly. Watch for reduced pazopanib effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Pazopanib?
MediHelp rates the interaction as moderate. Deferasirox and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and reduce pazopanib exposure, though the effect is not well characterized. Both drugs can also affect liver and kidney function.
How serious is the interaction between Deferasirox and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and renal function regularly. Watch for reduced pazopanib effect.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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