Drug interactions
Deferasirox + Quinine
Severity: Moderate
Deferasirox and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower quinine exposure, which could reduce antimalarial efficacy. The effect is predicted from the mechanism and is not well characterized clinically.
What this interaction means in plain words
Deferasirox and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Quinine belongs to Anti Parasitic.
Why it happens
Deferasirox may induce CYP3A4-mediated metabolism of quinine, although it also inhibits other CYP enzymes.
What to do
Monitor clinical response to quinine, and consider an alternative antimalarial if treatment response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Quinine?
MediHelp rates the interaction as moderate. Deferasirox and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and lower quinine exposure, which could reduce antimalarial efficacy. The effect is predicted from the mechanism and is not well characterized clinically.
How serious is the interaction between Deferasirox and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to quinine, and consider an alternative antimalarial if treatment response is inadequate.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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