Drug interactions
Deferasirox + Rasagiline
Severity: Moderate
Deferasirox and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is cleared mainly by CYP1A2, and deferasirox is a moderate CYP1A2 inhibitor. Rasagiline concentrations may rise, increasing the likelihood of dose-related adverse effects.
What this interaction means in plain words
Deferasirox and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.
Why it happens
Deferasirox inhibits CYP1A2, reducing the metabolism of rasagiline.
What to do
Monitor for rasagiline adverse effects such as orthostatic hypotension, dyskinesia and hallucinations. Consider limiting rasagiline to the lower dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Rasagiline?
MediHelp rates the interaction as moderate. Deferasirox and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is cleared mainly by CYP1A2, and deferasirox is a moderate CYP1A2 inhibitor. Rasagiline concentrations may rise, increasing the likelihood of dose-related adverse effects.
How serious is the interaction between Deferasirox and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rasagiline adverse effects such as orthostatic hypotension, dyskinesia and hallucinations. Consider limiting rasagiline to the lower dose if needed.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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