Drug interactions
Deferasirox + Ropinirole
Severity: Moderate
Deferasirox and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2 and can increase exposure to CYP1A2 substrates such as ropinirole. This may increase dopaminergic adverse effects including somnolence, nausea and orthostatic hypotension.
What this interaction means in plain words
Deferasirox and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Ropinirole belongs to Central Nervous System.
Why it happens
Deferasirox inhibits CYP1A2, reducing ropinirole clearance.
What to do
Monitor for ropinirole adverse effects and consider a lower dose when starting deferasirox. Readjust when deferasirox is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ropinirole?
MediHelp rates the interaction as moderate. Deferasirox and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2 and can increase exposure to CYP1A2 substrates such as ropinirole. This may increase dopaminergic adverse effects including somnolence, nausea and orthostatic hypotension.
How serious is the interaction between Deferasirox and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ropinirole adverse effects and consider a lower dose when starting deferasirox. Readjust when deferasirox is stopped.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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