Drug interactions
Deferasirox + Streptomycin
Severity: Moderate
Deferasirox and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause acute kidney injury and renal tubular toxicity, and streptomycin is nephrotoxic and ototoxic. Using them together raises the risk of kidney damage and can further impair clearance of streptomycin, increasing toxicity.
What this interaction means in plain words
Deferasirox and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity from two agents that injure renal tubular cells.
What to do
Monitor serum creatinine or creatinine clearance before and during combined therapy, and monitor streptomycin levels. Reduce or interrupt a drug if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Streptomycin?
MediHelp rates the interaction as moderate. Deferasirox and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause acute kidney injury and renal tubular toxicity, and streptomycin is nephrotoxic and ototoxic. Using them together raises the risk of kidney damage and can further impair clearance of streptomycin, increasing toxicity.
How serious is the interaction between Deferasirox and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine or creatinine clearance before and during combined therapy, and monitor streptomycin levels. Reduce or interrupt a drug if renal function declines.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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