Drug interactions
Deferasirox + Tadalafil
Severity: Moderate
Deferasirox and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 in some patients, which may lower tadalafil concentrations and reduce its effect. It is more relevant when tadalafil is used for pulmonary hypertension.
What this interaction means in plain words
Deferasirox and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Tadalafil belongs to Genitourinary.
Why it happens
Deferasirox may induce CYP3A4 and increase tadalafil clearance, although it also inhibits CYP2C8 and CYP1A2.
What to do
Monitor clinical response to tadalafil, including exercise capacity in pulmonary hypertension or erectile response. Adjust the tadalafil dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Tadalafil?
MediHelp rates the interaction as moderate. Deferasirox and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 in some patients, which may lower tadalafil concentrations and reduce its effect. It is more relevant when tadalafil is used for pulmonary hypertension.
How serious is the interaction between Deferasirox and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tadalafil, including exercise capacity in pulmonary hypertension or erectile response. Adjust the tadalafil dose if efficacy declines.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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