Drug interactions
Deferasirox + Tolmetin
Severity: Major
Deferasirox and Tolmetin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the gastrointestinal mucosa and deferasirox has itself been associated with GI hemorrhage and ulceration. Together with an NSAID the risk of GI bleeding is increased, and both can also affect renal function.
What this interaction means in plain words
Deferasirox and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity, with NSAID inhibition of platelet function and prostaglandin-mediated mucosal protection.
What to do
Avoid concurrent use where possible, particularly in older patients or those with low platelet counts. If unavoidable, give gastroprotection and monitor for GI bleeding, hemoglobin and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Tolmetin?
MediHelp rates the interaction as major. Deferasirox and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the gastrointestinal mucosa and deferasirox has itself been associated with GI hemorrhage and ulceration. Together with an NSAID the risk of GI bleeding is increased, and both can also affect renal function.
How serious is the interaction between Deferasirox and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, particularly in older patients or those with low platelet counts. If unavoidable, give gastroprotection and monitor for GI bleeding, hemoglobin and renal function.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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