Drug interactions
Deferasirox + Tolvaptan
Severity: Moderate
Deferasirox and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is a sensitive CYP3A4 substrate and deferasirox can weakly induce CYP3A4. Tolvaptan levels may fall, reducing its aquaretic effect and blunting sodium correction.
What this interaction means in plain words
Deferasirox and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Deferasirox induces CYP3A4, accelerating tolvaptan metabolism.
What to do
Monitor serum sodium and fluid status when starting or stopping deferasirox. Increase the tolvaptan dose if the response is inadequate, within labeled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deferasirox and Tolvaptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Deferasirox
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Deferasirox with Tolvaptan?
MediHelp rates the interaction as moderate. Deferasirox and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan is a sensitive CYP3A4 substrate and deferasirox can weakly induce CYP3A4. Tolvaptan levels may fall, reducing its aquaretic effect and blunting sodium correction.
How serious is the interaction between Deferasirox and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status when starting or stopping deferasirox. Increase the tolvaptan dose if the response is inadequate, within labeled limits.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
