Drug interactions
Deferiprone + Edetate calcium disodium
Severity: Moderate
Deferiprone and Edetate calcium disodium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone carries a risk of agranulocytosis, and edetate calcium disodium has been associated with bone marrow effects. Concurrent use may add to hematologic toxicity, and both agents are nephrotoxic or chelating.
What this interaction means in plain words
Deferiprone and Edetate calcium disodium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive hematologic toxicity; the interaction is largely theoretical.
What to do
Avoid concurrent use unless essential, and monitor absolute neutrophil count and renal function if both are given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Edetate calcium disodium?
MediHelp rates the interaction as moderate. Deferiprone and Edetate calcium disodium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone carries a risk of agranulocytosis, and edetate calcium disodium has been associated with bone marrow effects. Concurrent use may add to hematologic toxicity, and both agents are nephrotoxic or chelating.
How serious is the interaction between Deferiprone and Edetate calcium disodium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless essential, and monitor absolute neutrophil count and renal function if both are given.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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