Drug interactions
Deferiprone + Magnesium supplement
Severity: Minor
Deferiprone and Magnesium supplement: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone forms complexes with divalent and trivalent cations, including magnesium, in the intestine. Oral magnesium supplements may therefore reduce the amount of deferiprone absorbed and weaken iron chelation.
What this interaction means in plain words
Deferiprone and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Chelation between deferiprone and magnesium ions in the gut lowers absorption.
What to do
Give the magnesium supplement at least 4 hours apart from deferiprone. Monitor serum ferritin for loss of chelation efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deferiprone and Magnesium supplement, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Magnesium supplement?
MediHelp rates the interaction as minor. Deferiprone and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferiprone forms complexes with divalent and trivalent cations, including magnesium, in the intestine. Oral magnesium supplements may therefore reduce the amount of deferiprone absorbed and weaken iron chelation.
How serious is the interaction between Deferiprone and Magnesium supplement?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the magnesium supplement at least 4 hours apart from deferiprone. Monitor serum ferritin for loss of chelation efficacy.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
