Drug interactions
Deferiprone + Polysaccharide iron
Severity: Moderate
Deferiprone and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone binds iron, so oral iron products can chelate the drug in the gut and lessen its absorption. Giving iron to a patient who is being treated for iron overload also works against therapeutic goals.
What this interaction means in plain words
Deferiprone and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of deferiprone by iron in the gastrointestinal tract reduces absorption and effect.
What to do
Avoid iron supplements unless a deficiency is clearly documented. If it is needed, separate doses by at least 4 hours and monitor ferritin and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Polysaccharide iron?
MediHelp rates the interaction as moderate. Deferiprone and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone binds iron, so oral iron products can chelate the drug in the gut and lessen its absorption. Giving iron to a patient who is being treated for iron overload also works against therapeutic goals.
How serious is the interaction between Deferiprone and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid iron supplements unless a deficiency is clearly documented. If it is needed, separate doses by at least 4 hours and monitor ferritin and hemoglobin.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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