Drug interactions
Deferiprone + Thalidomide
Severity: Moderate
Deferiprone and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide can cause neutropenia and leukopenia. Used with deferiprone, additive neutropenia is possible.
What this interaction means in plain words
Deferiprone and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Thalidomide belongs to Miscellaneous.
Why it happens
Additive neutropenic effects.
What to do
Monitor absolute neutrophil count more frequently than the routine weekly check, and interrupt deferiprone if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Thalidomide
Frequently asked questions
Can I take Deferiprone with Thalidomide?
MediHelp rates the interaction as moderate. Deferiprone and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide can cause neutropenia and leukopenia. Used with deferiprone, additive neutropenia is possible.
How serious is the interaction between Deferiprone and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor absolute neutrophil count more frequently than the routine weekly check, and interrupt deferiprone if neutropenia develops.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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