Drug interactions
Deflazacort + Diltiazem
Severity: Moderate
Deflazacort and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem increases exposure to the active metabolite of deflazacort, which may increase corticosteroid adverse effects such as infection risk, hyperglycaemia and Cushingoid features.
What this interaction means in plain words
Deflazacort and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Diltiazem belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition by diltiazem reduces clearance of deflazacort's active metabolite.
What to do
Reduce the deflazacort dose to one third of the recommended dose as per labelling. Monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Diltiazem?
MediHelp rates the interaction as moderate. Deflazacort and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem increases exposure to the active metabolite of deflazacort, which may increase corticosteroid adverse effects such as infection risk, hyperglycaemia and Cushingoid features.
How serious is the interaction between Deflazacort and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to one third of the recommended dose as per labelling. Monitor for corticosteroid adverse effects.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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