Drug interactions
Deflazacort + Diphtheria and tetanus toxoids / acellular pertussis vaccine
Severity: Moderate
Deflazacort and Diphtheria and tetanus toxoids / acellular pertussis vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort may blunt the antibody response to this inactivated combination vaccine, leaving protection suboptimal. There is no risk of vaccine-strain infection because the components are non-live.
What this interaction means in plain words
Deflazacort and Diphtheria and tetanus toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression reduces antigen-specific lymphocyte and antibody responses.
What to do
Give the vaccine when indicated, ideally before starting therapy or at the lowest steroid dose. Consider revaccination or serology after steroids are stopped if the response matters clinically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Diphtheria and tetanus toxoids / acellular pertussis vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as moderate. Deflazacort and Diphtheria and tetanus toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort may blunt the antibody response to this inactivated combination vaccine, leaving protection suboptimal. There is no risk of vaccine-strain infection because the components are non-live.
How serious is the interaction between Deflazacort and Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine when indicated, ideally before starting therapy or at the lowest steroid dose. Consider revaccination or serology after steroids are stopped if the response matters clinically.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
