Drug interactions
Deflazacort + Diphtheria and tetanus toxoids
Severity: Moderate
Deflazacort and Diphtheria and tetanus toxoids: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can reduce antibody responses to inactivated toxoid vaccines, so protection may be lower than expected. Because the vaccine is non-live, there is no risk of vaccine-related infection.
What this interaction means in plain words
Deflazacort and Diphtheria and tetanus toxoids can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression dampens lymphocyte activation and antibody production after vaccination.
What to do
Vaccination does not need to be withheld when it is indicated, for example for wound management; where possible, vaccinate before starting therapy or during lower-dose periods. Consider checking antibody titres or repeating the dose after steroid withdrawal if the response is in doubt.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Diphtheria and tetanus toxoids?
MediHelp rates the interaction as moderate. Deflazacort and Diphtheria and tetanus toxoids can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can reduce antibody responses to inactivated toxoid vaccines, so protection may be lower than expected. Because the vaccine is non-live, there is no risk of vaccine-related infection.
How serious is the interaction between Deflazacort and Diphtheria and tetanus toxoids?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination does not need to be withheld when it is indicated, for example for wound management; where possible, vaccinate before starting therapy or during lower-dose periods. Consider checking antibody titres or repeating the dose after steroid withdrawal if the response is in doubt.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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