Drug interactions
Deflazacort + Encorafenib
Severity: Moderate
Deflazacort and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so its effect on deflazacort exposure is unpredictable. Deflazacort's active metabolite may be increased, raising corticosteroid adverse effects, or decreased, reducing efficacy.
What this interaction means in plain words
Deflazacort and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters the metabolism of the deflazacort active metabolite.
What to do
Monitor clinical response and corticosteroid adverse effects, and adjust the deflazacort dose if effect appears increased or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Deflazacort with Encorafenib?
MediHelp rates the interaction as moderate. Deflazacort and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so its effect on deflazacort exposure is unpredictable. Deflazacort's active metabolite may be increased, raising corticosteroid adverse effects, or decreased, reducing efficacy.
How serious is the interaction between Deflazacort and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and corticosteroid adverse effects, and adjust the deflazacort dose if effect appears increased or reduced.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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