Drug interactions
Deflazacort + Epinephrine
Severity: Minor
Deflazacort and Epinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine drives potassium into cells through beta-2 stimulation, and corticosteroids promote renal potassium loss. Together, hypokalemia may be enhanced, mostly with repeated or high-dose epinephrine.
What this interaction means in plain words
Deflazacort and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Epinephrine belongs to Endocrine.
Why it happens
Beta-2 mediated intracellular potassium shift from epinephrine combined with corticosteroid-induced renal potassium excretion.
What to do
Monitor serum potassium when epinephrine is given repeatedly or by infusion. Correct hypokalemia if it develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Deflazacort with Epinephrine?
MediHelp rates the interaction as minor. Deflazacort and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine drives potassium into cells through beta-2 stimulation, and corticosteroids promote renal potassium loss. Together, hypokalemia may be enhanced, mostly with repeated or high-dose epinephrine.
How serious is the interaction between Deflazacort and Epinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when epinephrine is given repeatedly or by infusion. Correct hypokalemia if it develops.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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