Drug interactions
Deflazacort + Glibenclamide
Severity: Moderate
Deflazacort and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that can raise blood glucose and therefore weaken the effect of glyburide. Patients may need more intensive diabetes treatment during glucocorticoid therapy, and hypoglycemia can follow when the steroid is reduced.
What this interaction means in plain words
Deflazacort and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Glibenclamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoids increase hepatic gluconeogenesis and induce insulin resistance.
What to do
Monitor blood glucose during deflazacort therapy and increase the glyburide dose or add other treatment if needed. Reassess the dose when the steroid is tapered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Glibenclamide?
MediHelp rates the interaction as moderate. Deflazacort and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that can raise blood glucose and therefore weaken the effect of glyburide. Patients may need more intensive diabetes treatment during glucocorticoid therapy, and hypoglycemia can follow when the steroid is reduced.
How serious is the interaction between Deflazacort and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during deflazacort therapy and increase the glyburide dose or add other treatment if needed. Reassess the dose when the steroid is tapered or stopped.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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