Drug interactions
Deflazacort + Glimepiride-pioglitazone
Severity: Moderate
Deflazacort and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that can raise blood glucose and weaken the effect of glimepiride and pioglitazone. Hyperglycemia is more likely with higher doses and long-term use.
What this interaction means in plain words
Deflazacort and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose production oppose antidiabetic therapy.
What to do
Monitor blood glucose during deflazacort therapy and increase antidiabetic therapy if needed, reducing it again when the steroid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Deflazacort and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that can raise blood glucose and weaken the effect of glimepiride and pioglitazone. Hyperglycemia is more likely with higher doses and long-term use.
How serious is the interaction between Deflazacort and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during deflazacort therapy and increase antidiabetic therapy if needed, reducing it again when the steroid is stopped.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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