Drug interactions
Deflazacort + Heparin
Severity: Moderate
Deflazacort and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can raise the risk of gastrointestinal ulceration and bleeding, and have variable reported effects on coagulation. Combined with heparin, bleeding risk may be modestly increased.
What this interaction means in plain words
Deflazacort and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Heparin belongs to Cardiovascular.
Why it happens
Steroid-related mucosal injury and vascular fragility add to heparin anticoagulation; direct effects on coagulation are inconsistent.
What to do
Monitor aPTT or anti-Xa and for signs of bleeding. Consider gastroprotection if prolonged steroid therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Heparin?
MediHelp rates the interaction as moderate. Deflazacort and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can raise the risk of gastrointestinal ulceration and bleeding, and have variable reported effects on coagulation. Combined with heparin, bleeding risk may be modestly increased.
How serious is the interaction between Deflazacort and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or anti-Xa and for signs of bleeding. Consider gastroprotection if prolonged steroid therapy is needed.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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