Drug interactions
Deflazacort + Hepatitis a / b vaccine
Severity: Moderate
Deflazacort and Hepatitis a / b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort can weaken seroconversion after this inactivated vaccine, so protective antibody levels may not be reached. The vaccine itself poses no infection risk.
What this interaction means in plain words
Deflazacort and Hepatitis a / b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression impairs B- and T-cell responses to vaccine antigens.
What to do
Vaccinate when indicated, ideally before steroid initiation. Check anti-HBs and anti-HAV levels after the series in patients on prolonged therapy and give boosters if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Hepatitis a / b vaccine?
MediHelp rates the interaction as moderate. Deflazacort and Hepatitis a / b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort can weaken seroconversion after this inactivated vaccine, so protective antibody levels may not be reached. The vaccine itself poses no infection risk.
How serious is the interaction between Deflazacort and Hepatitis a / b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated, ideally before steroid initiation. Check anti-HBs and anti-HAV levels after the series in patients on prolonged therapy and give boosters if needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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