Drug interactions
Deflazacort + Hepatitis b vaccine
Severity: Moderate
Deflazacort and Hepatitis b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can lower the rate and magnitude of seroconversion after hepatitis B vaccination. The vaccine is non-live and carries no infection risk.
What this interaction means in plain words
Deflazacort and Hepatitis b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression reduces antigen-specific antibody responses.
What to do
Vaccinate when indicated, ideally before starting steroids. Measure anti-HBs after the series and give additional doses if the titre is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Hepatitis b vaccine?
MediHelp rates the interaction as moderate. Deflazacort and Hepatitis b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can lower the rate and magnitude of seroconversion after hepatitis B vaccination. The vaccine is non-live and carries no infection risk.
How serious is the interaction between Deflazacort and Hepatitis b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated, ideally before starting steroids. Measure anti-HBs after the series and give additional doses if the titre is inadequate.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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