Drug interactions
Deflazacort + Hydrochlorothiazide-olmesartan
Severity: Moderate
Deflazacort and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid with some mineralocorticoid activity that can promote potassium loss. Together with the thiazide component, this can lead to hypokalemia, which may cause arrhythmias or muscle weakness. Olmesartan reduces the risk only partially.
What this interaction means in plain words
Deflazacort and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from thiazide diuresis and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium during combined use, particularly with prolonged or high-dose steroid therapy. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Deflazacort and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a corticosteroid with some mineralocorticoid activity that can promote potassium loss. Together with the thiazide component, this can lead to hypokalemia, which may cause arrhythmias or muscle weakness. Olmesartan reduces the risk only partially.
How serious is the interaction between Deflazacort and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during combined use, particularly with prolonged or high-dose steroid therapy. Replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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