Drug interactions
Deflazacort + Indapamide
Severity: Moderate
Deflazacort and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids like deflazacort promote potassium loss, and indapamide does the same, so hypokalemia may be more frequent or severe. Low potassium can cause weakness and arrhythmias.
What this interaction means in plain words
Deflazacort and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Indapamide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from mineralocorticoid activity of the corticosteroid and thiazide-like diuretic action.
What to do
Monitor serum potassium and magnesium regularly and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Indapamide?
MediHelp rates the interaction as moderate. Deflazacort and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids like deflazacort promote potassium loss, and indapamide does the same, so hypokalemia may be more frequent or severe. Low potassium can cause weakness and arrhythmias.
How serious is the interaction between Deflazacort and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and supplement as needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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