Drug interactions
Deflazacort + Influenza virus vaccine quadrivalent
Severity: Minor
Deflazacort and Influenza virus vaccine quadrivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort may reduce the antibody response to inactivated influenza vaccine, so protection may be partial. Vaccination remains recommended because influenza is more dangerous in immunosuppressed patients.
What this interaction means in plain words
Deflazacort and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid immunosuppression modestly reduces the humoral response to vaccine antigens.
What to do
Give the annual inactivated vaccine as usual without interrupting deflazacort. Encourage vaccination of close contacts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as minor. Deflazacort and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deflazacort may reduce the antibody response to inactivated influenza vaccine, so protection may be partial. Vaccination remains recommended because influenza is more dangerous in immunosuppressed patients.
How serious is the interaction between Deflazacort and Influenza virus vaccine quadrivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the annual inactivated vaccine as usual without interrupting deflazacort. Encourage vaccination of close contacts.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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