Drug interactions
Deflazacort + Influenza virus vaccine trivalent recombinant
Severity: Moderate
Deflazacort and Influenza virus vaccine trivalent recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may blunt the antibody response to vaccination, particularly at immunosuppressive doses. The recombinant vaccine is non-live and safe to give, but protection may be lower.
What this interaction means in plain words
Deflazacort and Influenza virus vaccine trivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated immunosuppression reduces lymphocyte activation and antibody production after vaccination.
What to do
Give the inactivated influenza vaccine as recommended and do not withhold it. Where feasible, vaccinate before starting long-term steroids, and consider the response may be reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Influenza virus vaccine trivalent recombinant?
MediHelp rates the interaction as moderate. Deflazacort and Influenza virus vaccine trivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids may blunt the antibody response to vaccination, particularly at immunosuppressive doses. The recombinant vaccine is non-live and safe to give, but protection may be lower.
How serious is the interaction between Deflazacort and Influenza virus vaccine trivalent recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated influenza vaccine as recommended and do not withhold it. Where feasible, vaccinate before starting long-term steroids, and consider the response may be reduced.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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