Drug interactions
Deflazacort + Insulin aspart
Severity: Moderate
Deflazacort and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin drives potassium into cells, and corticosteroids such as deflazacort can promote renal potassium loss through mineralocorticoid activity. Together they may lower serum potassium. Deflazacort also raises blood glucose, which can reduce the effect of insulin.
What this interaction means in plain words
Deflazacort and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin aspart belongs to Endocrine.
Why it happens
Additive potassium lowering through insulin-driven cellular uptake and corticosteroid-induced renal potassium wasting, plus glucocorticoid antagonism of insulin action.
What to do
Monitor serum potassium and blood glucose when deflazacort is started, changed or stopped. Adjust the insulin dose as needed and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Insulin aspart, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin aspart
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin aspart?
MediHelp rates the interaction as moderate. Deflazacort and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin drives potassium into cells, and corticosteroids such as deflazacort can promote renal potassium loss through mineralocorticoid activity. Together they may lower serum potassium. Deflazacort also raises blood glucose, which can reduce the effect of insulin.
How serious is the interaction between Deflazacort and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood glucose when deflazacort is started, changed or stopped. Adjust the insulin dose as needed and replace potassium if low.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
