Drug interactions
Deflazacort + Insulin detemir
Severity: Moderate
Deflazacort and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that raises blood glucose and so can oppose insulin's effect, while both drugs can lower serum potassium. Patients may need higher insulin doses and potassium monitoring.
What this interaction means in plain words
Deflazacort and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin detemir belongs to Endocrine.
Why it happens
Glucocorticoids cause insulin resistance and increased hepatic glucose output, and both agents promote potassium loss or intracellular shift.
What to do
Monitor blood glucose and serum potassium, and increase the insulin dose as needed during deflazacort therapy. Reduce insulin when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin detemir?
MediHelp rates the interaction as moderate. Deflazacort and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that raises blood glucose and so can oppose insulin's effect, while both drugs can lower serum potassium. Patients may need higher insulin doses and potassium monitoring.
How serious is the interaction between Deflazacort and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and increase the insulin dose as needed during deflazacort therapy. Reduce insulin when the steroid is tapered.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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