Drug interactions
Deflazacort + Insulin lispro protamine / insulin lispro
Severity: Moderate
Deflazacort and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids cause insulin resistance and hyperglycemia, which can reduce the effectiveness of insulin and raise insulin requirements. Insulin also lowers potassium, and combined potassium-lowering effects are possible.
What this interaction means in plain words
Deflazacort and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing insulin action; insulin shifts potassium into cells.
What to do
Monitor blood glucose more frequently when starting, changing or stopping deflazacort and adjust the insulin dose. Check serum potassium if risk factors for hypokalemia exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Deflazacort and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids cause insulin resistance and hyperglycemia, which can reduce the effectiveness of insulin and raise insulin requirements. Insulin also lowers potassium, and combined potassium-lowering effects are possible.
How serious is the interaction between Deflazacort and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, changing or stopping deflazacort and adjust the insulin dose. Check serum potassium if risk factors for hypokalemia exist.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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