Drug interactions
Deflazacort + Insulin lispro
Severity: Moderate
Deflazacort and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that raises blood glucose and can lower serum potassium, which opposes the glucose-lowering effect of insulin. Insulin also shifts potassium into cells, so the combination may add to hypokalemia and leave glycemic control unpredictable.
What this interaction means in plain words
Deflazacort and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin lispro belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and mineralocorticoid-related potassium loss, combined with insulin-driven cellular potassium uptake.
What to do
Monitor blood glucose and serum potassium when starting, changing or stopping deflazacort, and adjust the insulin dose as needed. Replace potassium if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Insulin lispro, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin lispro
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin lispro?
MediHelp rates the interaction as moderate. Deflazacort and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that raises blood glucose and can lower serum potassium, which opposes the glucose-lowering effect of insulin. Insulin also shifts potassium into cells, so the combination may add to hypokalemia and leave glycemic control unpredictable.
How serious is the interaction between Deflazacort and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when starting, changing or stopping deflazacort, and adjust the insulin dose as needed. Replace potassium if hypokalemia develops.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
