Drug interactions
Deflazacort + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Deflazacort and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort, a glucocorticoid, raises blood glucose and can reduce the effectiveness of insulin, so higher insulin doses may be needed. Both agents can lower potassium, which may add to hypokalemia risk.
What this interaction means in plain words
Deflazacort and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output oppose insulin; both drugs also shift or lose potassium.
What to do
Monitor glucose and increase insulin as needed during deflazacort therapy, reducing it again when the steroid is stopped. Check serum potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Insulin neutral human-insulin isophane protamine human, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Deflazacort and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort, a glucocorticoid, raises blood glucose and can reduce the effectiveness of insulin, so higher insulin doses may be needed. Both agents can lower potassium, which may add to hypokalemia risk.
How serious is the interaction between Deflazacort and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and increase insulin as needed during deflazacort therapy, reducing it again when the steroid is stopped. Check serum potassium periodically.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
