Drug interactions
Deflazacort + Isoniazid
Severity: Minor
Deflazacort and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may weakly inhibit CYP3A4 and increase exposure to the active metabolite of deflazacort. This could increase corticosteroid adverse effects, though the effect is likely small.
What this interaction means in plain words
Deflazacort and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid reducing metabolism of deflazacort's active metabolite.
What to do
Monitor for corticosteroid effects such as fluid retention, hyperglycemia and infection. Consider a lower deflazacort dose if effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Isoniazid?
MediHelp rates the interaction as minor. Deflazacort and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may weakly inhibit CYP3A4 and increase exposure to the active metabolite of deflazacort. This could increase corticosteroid adverse effects, though the effect is likely small.
How serious is the interaction between Deflazacort and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid effects such as fluid retention, hyperglycemia and infection. Consider a lower deflazacort dose if effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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