Drug interactions
Deflazacort + Ketorolac intranasal
Severity: Moderate
Deflazacort and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs raise the risk of gastrointestinal irritation, ulceration and bleeding. Intranasal ketorolac gives systemic exposure, so the risk remains relevant, especially with prolonged use.
What this interaction means in plain words
Deflazacort and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects on mucosal healing.
What to do
Limit ketorolac to the shortest course and monitor for GI symptoms or bleeding. Consider gastroprotection in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Deflazacort and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs raise the risk of gastrointestinal irritation, ulceration and bleeding. Intranasal ketorolac gives systemic exposure, so the risk remains relevant, especially with prolonged use.
How serious is the interaction between Deflazacort and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course and monitor for GI symptoms or bleeding. Consider gastroprotection in patients with additional risk factors.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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