Drug interactions
Deflazacort + Lonapegsomatropin
Severity: Minor
Deflazacort and Lonapegsomatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which converts inactive cortisone into cortisol. Starting growth hormone can lower cortisol availability, and may reduce the effect of cortisone-type glucocorticoids that need this activation.
What this interaction means in plain words
Deflazacort and Lonapegsomatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Lonapegsomatropin belongs to Endocrine.
Why it happens
Inhibition of 11-beta-HSD1 by growth hormone reduces local cortisol regeneration; deflazacort is an active-metabolite prodrug not dependent on this enzyme.
What to do
Monitor for adrenal insufficiency symptoms after starting lonapegsomatropin in patients on replacement glucocorticoids, and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Deflazacort with Lonapegsomatropin?
MediHelp rates the interaction as minor. Deflazacort and Lonapegsomatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which converts inactive cortisone into cortisol. Starting growth hormone can lower cortisol availability, and may reduce the effect of cortisone-type glucocorticoids that need this activation.
How serious is the interaction between Deflazacort and Lonapegsomatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adrenal insufficiency symptoms after starting lonapegsomatropin in patients on replacement glucocorticoids, and adjust the dose if needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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