Drug interactions
Deflazacort + Lubiprostone
Severity: Minor
Deflazacort and Lubiprostone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lubiprostone can cause diarrhea and corticosteroids promote renal potassium loss, so potassium depletion may be additive. Clinically significant hypokalemia is more likely with prolonged use or other potassium-lowering drugs.
What this interaction means in plain words
Deflazacort and Lubiprostone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Lubiprostone belongs to Gastrointestinal Tract.
Why it happens
Additive potassium loss via renal excretion (corticosteroid) and gastrointestinal fluid loss (lubiprostone-induced diarrhea).
What to do
Monitor serum potassium if diarrhea develops or therapy is prolonged, and replace as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Lubiprostone
- Linaclotide + Lubiprostone Moderate
- Lubiprostone + Mosapride Moderate
Frequently asked questions
Can I take Deflazacort with Lubiprostone?
MediHelp rates the interaction as minor. Deflazacort and Lubiprostone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lubiprostone can cause diarrhea and corticosteroids promote renal potassium loss, so potassium depletion may be additive. Clinically significant hypokalemia is more likely with prolonged use or other potassium-lowering drugs.
How serious is the interaction between Deflazacort and Lubiprostone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if diarrhea develops or therapy is prolonged, and replace as needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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