Drug interactions
Deflazacort + Measles vaccine
Severity: Contraindicated
Deflazacort and Measles vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Measles vaccine contains live attenuated virus that may cause disseminated disease in a patient immunosuppressed by deflazacort. The vaccine response may also be inadequate.
What this interaction means in plain words
Deflazacort and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Glucocorticoid immunosuppression impairs control of live attenuated virus replication and blunts immunity.
What to do
Do not give at immunosuppressive doses; vaccinate at least the labeled interval after stopping steroids, or before starting them. For exposure, consider immunoglobulin rather than vaccine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Measles vaccine?
MediHelp rates the interaction as contraindicated. Deflazacort and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine contains live attenuated virus that may cause disseminated disease in a patient immunosuppressed by deflazacort. The vaccine response may also be inadequate.
How serious is the interaction between Deflazacort and Measles vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give at immunosuppressive doses; vaccinate at least the labeled interval after stopping steroids, or before starting them. For exposure, consider immunoglobulin rather than vaccine.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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