Drug interactions
Deflazacort + Metaproterenol
Severity: Moderate
Deflazacort and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower serum potassium, and the effect may be additive, especially with high-dose or repeated metaproterenol. Hypokalemia can promote arrhythmias and muscle weakness.
What this interaction means in plain words
Deflazacort and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonists shift potassium into cells, while corticosteroids promote renal potassium loss.
What to do
Monitor serum potassium when high or frequent doses of metaproterenol are used with deflazacort, particularly in patients with cardiac disease or other hypokalemic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Metaproterenol?
MediHelp rates the interaction as moderate. Deflazacort and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower serum potassium, and the effect may be additive, especially with high-dose or repeated metaproterenol. Hypokalemia can promote arrhythmias and muscle weakness.
How serious is the interaction between Deflazacort and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when high or frequent doses of metaproterenol are used with deflazacort, particularly in patients with cardiac disease or other hypokalemic drugs.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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