Drug interactions
Deflazacort + Metformin-sitagliptin
Severity: Moderate
Deflazacort and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a systemic glucocorticoid that can raise blood glucose and reduce the effectiveness of antidiabetic therapy. Higher doses and longer courses make this more likely.
What this interaction means in plain words
Deflazacort and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and insulin resistance, opposing the glucose-lowering effects of metformin and sitagliptin.
What to do
Monitor blood glucose during corticosteroid therapy and adjust antidiabetic doses if needed, then reassess when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Deflazacort and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a systemic glucocorticoid that can raise blood glucose and reduce the effectiveness of antidiabetic therapy. Higher doses and longer courses make this more likely.
How serious is the interaction between Deflazacort and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and adjust antidiabetic doses if needed, then reassess when the steroid is tapered.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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