Drug interactions
Deflazacort + Metformin
Severity: Moderate
Deflazacort and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort, a glucocorticoid, raises blood glucose and can offset the effect of metformin. Glycemic control may deteriorate during steroid therapy.
What this interaction means in plain words
Deflazacort and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Metformin belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output oppose metformin.
What to do
Monitor glucose during and after deflazacort therapy. Increase the antidiabetic regimen if needed and reduce it when the steroid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Metformin?
MediHelp rates the interaction as moderate. Deflazacort and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort, a glucocorticoid, raises blood glucose and can offset the effect of metformin. Glycemic control may deteriorate during steroid therapy.
How serious is the interaction between Deflazacort and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose during and after deflazacort therapy. Increase the antidiabetic regimen if needed and reduce it when the steroid is stopped.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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