Drug interactions
Deflazacort + Netupitant / palonosetron
Severity: Moderate
Deflazacort and Netupitant / palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and may increase exposure to deflazacort's active metabolite. Corticosteroid effects may be enhanced, although exposure is usually short-term with antiemetic use.
What this interaction means in plain words
Deflazacort and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Netupitant inhibits CYP3A4, reducing clearance of deflazacort's active metabolite.
What to do
Reduce deflazacort to one-third of the usual dose when used with moderate CYP3A4 inhibitors, per labeling. Monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Netupitant / palonosetron?
MediHelp rates the interaction as moderate. Deflazacort and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a moderate CYP3A4 inhibitor and may increase exposure to deflazacort's active metabolite. Corticosteroid effects may be enhanced, although exposure is usually short-term with antiemetic use.
How serious is the interaction between Deflazacort and Netupitant / palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce deflazacort to one-third of the usual dose when used with moderate CYP3A4 inhibitors, per labeling. Monitor for corticosteroid adverse effects.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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