Drug interactions
Deflazacort + Ofatumumab sc
Severity: Moderate
Deflazacort and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, so using them together may add to the risk of infections. Deflazacort is a systemic corticosteroid and ofatumumab depletes B cells, an effect that persists for months after the last dose.
What this interaction means in plain words
Deflazacort and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from glucocorticoid effects and CD20-mediated B-cell depletion.
What to do
Screen for active infection before treatment and monitor for signs of infection throughout therapy. Use the lowest effective corticosteroid dose and for the shortest period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Ofatumumab sc?
MediHelp rates the interaction as moderate. Deflazacort and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, so using them together may add to the risk of infections. Deflazacort is a systemic corticosteroid and ofatumumab depletes B cells, an effect that persists for months after the last dose.
How serious is the interaction between Deflazacort and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for active infection before treatment and monitor for signs of infection throughout therapy. Use the lowest effective corticosteroid dose and for the shortest period.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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